Berkeley

How Chronic Stress Predisposes Brain to Mental Illness

Published

11 years ago

February 17, 2014

By Robert Sanders, UC Berkeley News

University of California, Berkeley, researchers have shown that chronic stress generates long-term changes in the brain that may explain why people suffering chronic stress are prone to mental problems such as anxiety and mood disorders later in life.

Their findings could lead to new therapies to reduce the risk of developing mental illness after stressful events.

Doctors know that people with stress-related illnesses, such as post-traumatic stress disorder (PTSD), have abnormalities in the brain, including differences in the amount of gray matter versus white matter.

Gray matter consists mostly of cells – neurons, which store and process information, and support cells called glia – while white matter is comprised of axons, which create a network of fibers that interconnect neurons. White matter gets its name from the white, fatty myelin sheath that surrounds the axons and speeds the flow of electrical signals from cell to cell.

How chronic stress creates these long-lasting changes in brain structure is a mystery that researchers are only now beginning to unravel.

In a series of experiments, Daniela Kaufer, UC Berkeley associate professor of integrative biology, and her colleagues, including graduate students Sundari Chetty and Aaron Freidman, discovered that chronic stress generates more myelin-producing cells and fewer neurons than normal.

This results in an excess of myelin – and thus, white matter – in some areas of the brain, which disrupts the delicate balance and timing of communication within the brain.

“We studied only one part of the brain, the hippocampus, but our findings could provide insight into how white matter is changing in conditions such as schizophrenia, autism, depression, suicide, ADHD and PTSD,” she said.

The hippocampus regulates memory and emotions, and plays a role in various emotional disorders.

Kaufer and her colleagues published their findings in the Feb. 11 issue of the journal Molecular Psychiatry.

Kaufer’s findings suggest a mechanism that may explain some changes in brain connectivity in people with PTSD, for example. One can imagine, she said, that PTSD patients could develop a stronger connectivity between the hippocampus and the amygdala – the seat of the brain’s fight or flight response – and lower than normal connectivity between the hippocampus and prefrontal cortex, which moderates our responses.

“You can imagine that if your amygdala and hippocampus are better connected, that could mean that your fear responses are much quicker, which is something you see in stress survivors,” she said. “On the other hand, if your connections are not so good to the prefrontal cortex, your ability to shut down responses is impaired. So, when you are in a stressful situation, the inhibitory pathways from the prefrontal cortex telling you not to get stressed don’t work as well as the amygdala shouting to the hippocampus, ‘This is terrible!’ You have a much bigger response than you should.”

She is involved in a study to test this hypothesis in PTSD patients, and continues to study brain changes in rodents subjected to chronic stress or to adverse environments in early life.

Kaufer’s lab, which conducts research on the molecular and cellular effects of acute and chronic stress, focused in this study on neural stem cells in the hippocampus of the brains of adult rats. These stem cells were previously thought to mature only into neurons or a type of glial cell called an astrocyte. The researchers found, however, that chronic stress also made stem cells in the hippocampus mature into another type of glial cell called an oligodendrocyte, which produces the myelin that sheaths nerve cells.

The finding, which they demonstrated in rats and cultured rat brain cells, suggests a key role for oligodendrocytes in long-term and perhaps permanent changes in the brain that could set the stage for later mental problems.

Oligodendrocytes also help form synapses – sites where one cell talks to another – and help control the growth pathway of axons, which make those synapse connections.

The fact that chronic stress also decreases the number of stem cells that mature into neurons could provide an explanation for how chronic stress also affects learning and memory, she said.

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Bay Area

Progressive Missionary Baptist Church of Berkeley Celebrates 90th Anniversary

Dr. Earl C. Stuckey, Sr., who has served as Progressive Missionary’s pastor since September 1977, said the church also delights in the fact that it has hosted only five pastors in its 90-year history, including Pastors James E. Moore, H. A. Green, F. Douglas Farrell, and Edward Stovall, who served for 37 years.

Published

3 weeks ago

May 16, 2025

Oakland Post

Progressive Missionary Baptist Poster. Dr. Earl C. Stuckey, Sr., Pastor of Progressive Missionary Baptist Church in Berkeley with his wife, Kay Frances Stuckey.

By Oakland Post Staff

The Progressive Missionary Baptist Church of Berkeley is celebrating its 90th church anniversary on Sunday, May 18 at 10 a.m. at 3301 King Street in Berkeley.

The celebration will feature Pastor Darnell Manuel of the Union Baptist Church in Vallejo as guest speaker, along with many other special presentations.

Those who wish to share in Progressive’s history can purchase a 100-page full-colored souvenir book for $25.

The church boasts a number of notable people who either regularly attended or became members of the church since its inception, including former Alameda County Supervisor Keith Carson, Oakland mayoral candidate Loren Taylor, and one of the organizers of the Gospel Music Workshop of America, Helen J. H. Stephens.

Pastor Stuckey often remarks how longevity flourishes at the church — it boasts 13 centenarians (people who have reached 100 years or more). Currently, it has one centenarian who is still surviving, Mrs. Dorothy Chambers, and 14 members who have reached 90 years or more.

Recently, on Feb.17, the pastor and his wife Kay Frances, celebrated their 73rd wedding anniversary.

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Activism

Faces Around the Bay: Author Karen Lewis Took the ‘Detour to Straight Street’

“My life has been a roller-coaster with an unlimited ride wristband! I was raised in Berkeley during the time of Ron Dellums, the Black Panthers, and People’s Park. I was a Hippie kid, my Auntie cut off all our hair so we could wear the natural styles like her and Angela Davis.

Published

1 month ago

April 28, 2025

Oakland Post

Karen Lewis. Courtesy photo.

By Barbara Fluhrer

I met Karen Lewis on a park bench in Berkeley. She wrote her story on the spot.

I got married young, then ended up getting divorced, raising two boys into men. After my divorce, I had a stroke that left me blind and paralyzed. I was homeless, lost in a fog with blurred vision.

Jesus healed me! I now have two beautiful grandkids. At 61, this age and this stage, I am finally free indeed. Our Lord Jesus Christ saved my soul. I now know how to be still. I lay at his feet. I surrender and just rest. My life and every step on my path have already been ordered. So, I have learned in this life…it’s nice to be nice. No stressing, just blessings. Pray for the best and deal with the rest.

Nobody is perfect, so forgive quickly and love easily!”

Lewis’ book “Detour to Straight Street” is available on Amazon.

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Golden State Warriors Program Is Inspiring Next Generation of Female Engineers

Breaking down barriers and biases that deter young girls from pursuing STEAM subjects is essential for creating a level playing field and ensuring equal opportunities for all. By challenging stereotypes and promoting a culture of inclusivity and diversity in STEAM fields, experts believe young girls can be empowered to pursue their interests and aspirations without limitations confidently. Encouraging mentorship, providing access to resources, and celebrating girls’ achievements in STEAM are all crucial steps in creating a supportive environment that fosters success.

Published

3 months ago

March 23, 2025

Oakland Post

Front Row: UC Berkeley Steel Bridge Team Back Row: Girls, Inc. Participants. Photo courtesy of the Golden State Warriors.

By Y’Anad Burrell

The Golden State Warriors and e-commerce giant Rakuten are joining forces to inspire the next generation of female engineers through Building STEAM Futures, part of The City Calls campaign.

Organizers say the initiative is founded on the idea that science, technology, engineering, arts, and mathematics (STEAM) are crucial fields for innovation and progress, and empowering young girls to pursue careers in these areas is more important than ever. Studies consistently show that girls are underrepresented in STEAM fields, resulting in a gender disparity that limits potential and hinders diversity.

On Saturday, March 8, International Women’s Day, the Warriors and Rakuten hosted 20 middle school girls from Girls Inc. of Alameda County at Chase Center’s Above the Rim for a hands-on bridge-building experience. The young girls from Girls, Inc. of Alameda County had an opportunity to design, build and test their own bridge prototypes and learn the fundamentals of bridge construction from the Engineering Alliance and the UC Berkeley Steel Bridge Team.

This STEAM experience for the girls followed the first session in January, where they took a behind-the-scenes tour of the Golden Gate Bridge, learning about its design and construction from industry experts. The City Calls campaign, tipped off with the unveiling the Warriors’ new bridge-themed City Edition jerseys and court design earlier this year.