Health
One Dose, Then Surgery: A New Way to Test Brain Tumor Drugs
MARILYNN MARCHIONE, AP Chief Medical Writer
Lori Simons took the bright orange pill at 3 a.m. Eight hours later, doctors sliced into her brain, looking for signs that the drug was working.
She is taking part in one of the most unusual cancer experiments in the nation. With special permission from the Food and Drug Administration and multiple drug companies, an Arizona hospital is testing medicines very early in development and never tried on brain tumors before.
Within a day of getting a single dose of one of these drugs, patients have their tumors removed and checked to see if the medicine had any effect. If it did, they can stay on an experimental drug that otherwise would not be available to them. If it did not, they can try something else, months sooner than they normally would find out that a drug had failed to help.
“They don’t lose any time,” said Dr. Nader Sanai, the doctor leading the study at Phoenix’s Barrow Neurological Institute.
Time is everything for people with glioblastoma, the most common and deadly type of brain tumor, the kind that killed Massachusetts Sen. Edward M. Kennedy in 2009. Even when surgeons think they got it all, the cancer usually grows back and proves fatal. The few drugs to treat these tumors have little effect — median survival is about 14 months.
“We’ve had an endless string of failures” to find better ones, Sanai said.
His study is for people whose cancer came back. Doctors use a stored sample from the original tumor to see if its growth is driven by any genes or pathways targeted by one of the experimental drugs in development. If so, they give that single dose of the new drug before surgery to remove the new tumor.
Then, the tumor tissue is examined under a microscope to see if the drug had its intended effect on the genes or pathways.
So far, the study has tested one drug from AstraZeneca PLC in four patients. Another drug, from Novartis, will be added soon.
“We’re trying to develop a portfolio of these” so there are many possible drugs available for new patients under a single “umbrella” study, Sanai said.
It is called a “phase zero” clinical trial because it comes before the usual three-phase experiments to determine a drug’s safety, ideal dose and effectiveness.
“We view this as a great thing, as something that will produce better drugs that have greater chance of working,” said Dr. Richard Pazdur, cancer drug chief at the FDA.
“Cost potentially will go down and certainly time will go down” for companies testing new drugs this way and patients seeking something that will help, he said.
Finding treatments for brain tumors is “a huge unmet medical need” that justifies trying a new approach, Pazdur said.
Dr. James Doroshow was involved in the only previous studies like this, done at the National Cancer Institute.
In the past, “if you had a new drug, you’d give it to a patient, you’d measure the blood levels, but very rarely would you have a way to know whether the presumed method of action was working in the patient,” he said.
The Arizona study gives a way to check that, because the tumor is removed right after the first dose is given. And if the drug does not work in any or few of the people who get it, the study could spare others a futile treatment, and limit the time and money a drug company invests.
“If you’re going to fail, you want to fail early and fail fast before you put thousands of patients into randomized trials,” Doroshow said.
The experimental drug did not appear to help Simons, a 55-year-old former pharmacist from Gold Canyon, an hour’s drive east of Phoenix. Doctors decided to try an older drug, Temodar, after her surgery in late October.
“The real interest in these kind of trials is not necessarily putting patients on these drugs but keeping them off drugs that aren’t going to work,” said Sanai, who treated Simons.
The patient said she had no regrets about participating.
“It’s a revolutionary trial. I think it will open up a pathway for many other drugs to be studied in this manner,” Simons said. “I go into this with no motive for me. It’s just for the future, people who have cancer like I do, and see what kind of treatments they can have.”
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Online:
Treatment options for brain cancer: http://1.usa.gov/ZqXBlz
American Cancer Society info: http://bit.ly/UJMhZG
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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP
Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Activism
Let’s Talk Health: Empowering Our Community with Health Literacy
At Covered California, we recognize that understanding health insurance is more than just choosing a plan –it’s about having the knowledge to make informed decisions that lead to healthier lives. That’s why this year’s open enrollment campaign, “Let’s Talk Health,” focuses on breaking down barriers and simplifying the complex language of health care.
By Dr. Monica Soni
Navigating health insurance can often feel overwhelming, especially for individuals and families who are new to the system or unsure about their options.
At Covered California, we recognize that understanding health insurance is more than just choosing a plan –it’s about having the knowledge to make informed decisions that lead to healthier lives. That’s why this year’s open enrollment campaign, “Let’s Talk Health,” focuses on breaking down barriers and simplifying the complex language of health care.
Health literacy is critical for achieving better outcomes, reducing disparities, and ensuring every African American and Black Californian — regardless of their income, ethnicity, or background — has access to quality care. By making health insurance simpler to understand, we empower individuals to access preventive services, manage chronic conditions, and avoid costly medical bills.
Breaking Barriers in African American and Black Communities
This year, “Let’s Talk Health” places a special focus on supporting African American and Black communities, where systemic inequities in health outcomes persist. These communities often face higher rates of chronic conditions and challenges in navigating the health care system. To address these disparities, Covered California partnered with trusted organizations to provide information, tips and resources.
In San Francisco, Andre Atkins, Director of Programs at Rafiki Coalition, led a dialogue with Dr. Kim Rhoads, Community Engagement Director at UCSF Helen Diller Family Comprehensive Cancer Center; Destiny Williams, Health and Wellness Program Manager at Rafiki Coalition; and myself.
These conversations play a vital role in the pursuit of health equity by sharing power and creating spaces where our community can learn, share experiences, ask questions and connect with advocates who work daily to understand their unique needs. Through these efforts, we reaffirm our dedication to fostering equity and inclusion in health care, ensuring that every voice is heard and supported.
Why Health Literacy Matters
Health literacy goes beyond understanding health care terms. It’s about empowerment. It equips individuals to make informed decisions, from choosing the right health plan to finding a provider to deliver preventive care and seeking mental health services. At Covered California, we provide tools and resources, such as side-by-side plan comparisons and financial assistance details, to ensure everyone can navigate their options confidently and access the care they need.
Taking the First Step
Whether you’re a student, part-time worker, family of four, open enrollment is your opportunity to prioritize your health and your future. This year’s open enrollment period runs from Nov. 1, 2024, to Jan. 31, 2025, and we’re here to assist you every step of the way.
Consumers must select a health plan by the Dec. 31 to receive coverage for the entire year, starting Jan. 1, 2025.
To find the plan that’s right for you, and take the first step toward a healthier tomorrow, visit CoveredCA.com and fill out the application yourself or put in your ZIP code and connect with a certified agent in your neighborhood who can guide you through your options. Together, we can break down barriers and ensure that all Californians have the tools to thrive.
Dr. Monica Soni, MD, is the Chief Medical Officer for Covered California, where she leads efforts in health equity, quality transformation, and clinical innovation. As a practicing board-certified internal medicine physician and health care leader with over a decade of experience, Dr. Soni is committed to improving affordability, access, and outcomes for all Californians.
Activism
Oakland Awarded $675,000 Grant to Reduce Lead Hazards
The award will assist in Oakland’s work to reduce lead hazards in older rental housing, especially in communities most impacted by housing instability. The City hired a consultant, Green and Healthy Homes Initiative, in 2024 to lead the technical aspect of the lead abatement work.
By Post Staff
The City of Oakland has won a $675,800 grant from Partnership for the Bay’s Future (PBF) that will fund a two-year fellow to work in the Housing and Community Development (HCD) Department to support the development of lead hazard abatement and proactive rental inspection initiatives.
The award will assist in Oakland’s work to reduce lead hazards in older rental housing, especially in communities most impacted by housing instability. The City hired a consultant, Green and Healthy Homes Initiative, in 2024 to lead the technical aspect of the lead abatement work. By exploring the integration of lead hazard abatement with proactive rental inspections, the fellow’s work will aim to improve living conditions for families at risk of exposure and create safer homes for Oakland’s residents.
“We are grateful for the support of Partnership for the Bay’s Future for this award,” said Emily Weinstein, HCD director. “Housing safety and habitability are top priorities for our work in the coming year, and this fellow will ensure specific attention is paid to creating equitable solutions.”
The fellow will be dedicated full-time for the next two years to facilitate collaboration between HCD, Planning and Building Department (PBD), and a coalition of community partners. The total benefit to the City of Oakland is at least $675,800, of which $220,000 goes to a collaborative of community organizations to support the work.
The Healthy Havenscourt Collaborative brings essential community expertise to the project, connecting Oakland residents with resources and ensuring the program aligns with their needs.
These partners will engage residents directly to shape the program and make sure their voices are central to its design and implementation.
Coalition partners include Regional Asthma Management and Prevention (RAMP), La Clinica de la Raza, EBALDC, and Black Cultural Zone – all of which form the Healthy Havenscourt collaborative.
Activism
Life After Domestic Violence: What My Work With Black Women Survivors Has Taught Me
Survivors sometimes lack awareness about the dynamics of healthy relationships, particularly when one has not been modeled for them at home. Media often minimizes domestic abuse, pushing the imagery of loyalty and love for one’s partner above everything — even harm.
By Paméla Michelle Tate, Ph.D., California Black Media Partners
It was the Monday morning after her husband had a “situation” involving their child, resulting in food flying in the kitchen and a broken plate.
Before that incident, tensions had been escalating, and after years of unhappiness, she finally garnered enough courage to go to the courthouse to file for a divorce.
She was sent to an on-site workshop, and the process seemed to be going well until the facilitator asked, “Have you experienced domestic abuse?” She quickly replied, “No, my husband has never hit me.”
The facilitator continued the questionnaire and asked, “Has your husband been emotionally abusive, sexually abusive, financially abusive, technologically abusive, or spiritually abusive?”
She thought about how he would thwart her plans to spend time with family and friends, the arguments, and the many years she held her tongue. She reflected on her lack of access to “their money,” him snooping in her purse, checking her social media, computer, and emails, and the angry blowups where physical threats were made against both her and their children.
At that moment, she realized she had been in a long-suffering domestic abuse relationship.
After reading this, you might not consider the relationship described above as abusive — or you might read her account and wonder, “How didn’t she know that she was in an abusive relationship?”
Survivors sometimes lack awareness about the dynamics of healthy relationships, particularly when one has not been modeled for them at home. Media often minimizes domestic abuse, pushing the imagery of loyalty and love for one’s partner above everything — even harm.
After working with survivors at Black Women Revolt Against Domestic Violence in San Francisco, California, I have learned a great deal from a variety of survivors. Here are some insights:
Abuse thrives in isolation.
Societal tolerance of abusive behavior is prevalent in the media, workplaces, and even churches, although there are societal rules about the dos and don’ts in relationships.
Survivors are groomed into isolation.
Survivors are emotionally abused and manipulated almost from the beginning of their relationships through love-bombing. They are encouraged or coerced into their own little “love nest,” isolating them from family and friends.
People who harm can be charismatic and fun.
Those outside the relationship often struggle to believe the abuser would harm their partner until they witness or experience the abusive behavior firsthand.
Survivors fear judgment.
Survivors fear being judged by family, friends, peers, and coworkers and are afraid to speak out.
Survivors often still love their partners.
This is not Stockholm Syndrome; it’s love. Survivors remember the good times and don’t want to see their partner jailed; they simply want the abuse to stop.
The financial toll of abuse is devastating.
According to the Allstate Foundation’s study, 74% of survivors cite lack of money as the main reason for staying in abusive relationships. Financial abuse often prevents survivors from renting a place to stay. Compounding this issue is the lack of availability of domestic abuse shelters.
The main thing I have learned from this work is that survivors are resilient and the true experts of their own stories and their paths to healing. So, when you encounter a survivor, please take a moment to acknowledge their journey to healing and applaud their strength and progress.
About the Author
Paméla Michelle Tate, Ph.D., is executive director of Black Women Revolt Against Domestic Violence in San Francisco.
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