By Tamara Shiloh

Percy Lavon Julian was a brilliant American chemist and businessman whose groundbreaking discoveries transformed the pharmaceutical industry.

Known for his innovative work in synthesizing medicinal drugs from plants, he was a pioneer who opened new doors in chemical synthesis. One of Julian’s most notable achievements was being the first to synthesize physostigmine, a natural product used to treat glaucoma. His groundbreaking methods for producing human hormones like progesterone and testosterone from plant sterols revolutionized the steroid drug industry. These methods paved the way for the affordable production of life-saving medications such as cortisone, corticosteroids, and artificial hormones for birth control.

Born in Montgomery, Ala., in 1899, Julian grew up during a time when educational opportunities for African Americans were severely limited. Despite these challenges, his parents — graduates of what later became Alabama State University — instilled in their children a deep belief in the power of education. Julian excelled academically, graduating valedictorian at Indiana’s DePauw University in 1920. While his dream was to pursue a doctorate in chemistry, racial barriers initially stood in his way. Undeterred, he eventually earned his Ph.D. from the University of Vienna in 1931, becoming one of the first African Americans to achieve this milestone.

Returning to the United States, Julian faced discrimination that made it difficult to secure academic or research positions. Despite being denied jobs due to his race — even from prestigious companies like DuPont — he persevered. His big break came at the Glidden Company, where he led the Soy Products Division. At Glidden, Julian spearheaded several important projects. He developed the world’s first plant for industrial-scale production of isolated soy protein, which served as an affordable alternative to milk in various products. During World War II, his refined soy protein was used to create Aer-O-Foam, a lifesaving firefighting foam for the U.S. Navy. This achievement earned him the NAACP’s Spingarn Medal in 1947. Later, Julian turned his focus to synthesizing hormones from plant sterols, revolutionizing the production of cortisone and other critical medications. His cost-effective methods made these treatments more widely available, improving the lives of countless patients worldwide. Eventually, he founded Julian Laboratories, Inc., solidifying his legacy as a leader in steroid chemistry and pharmaceutical innovation. Julian Laboratories chemists found a way to quadruple the yield on a product on which they were barely breaking even. Julian reduced their price per kg for the product from $4,000 to $400. He sold the company in 1961 for $2.3 million (equivalent to $23 million today) and became one of the first Black millionaires.

The U.S. and Mexico facilities were purchased by Smith Kline, and Julian’s chemical plant in Guatemala was purchased by Upjohn. In 1964, Julian founded Julian Associates and Julian Research Institute, which he managed for the rest of his life.

Julian also helped to establish the Legal Defense and Educational Fund of Chicago.

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