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UCSF Researchers Probe Link Between Bacteria and Asthma

Published

12 years ago

June 11, 2014

Infants exposed to a diverse range of bacterial species in house dust during the first year of life appear to be bless likely to develop asthma in early childhood, according to a new study published online on June 6, 2014, in the Journal of Allergy and Clinical Immunology.

Children who were neither allergic nor prone to wheezing as three-year-olds were the most likely to have been exposed to high levels of bacteria, and paradoxically, to high levels of common allergens.

In fact, some of the protective bacteria are abundant in cockroaches and mice, the source of these common allergens, according to UC San Francisco researcher Susan Lynch, PhD, a lead author for the multi-institutional study.

Lynch also found that exposure during the first year of life to household dust containing higher levels of two specific groups of bacteria that are abundant in the human gut – Bacteriodes and Firmicutes – was associated with less asthma risk in the analysis of data from 104 inner-city babies in four cities.

Lynch, an associate professor of medicine with the Division of Gastroenterology at UCSF, said there is no obvious mechanism explaining the association, but the evidence supports earlier research that strongly pointed to the influence of microbial species in shaping immune responses.

The new microbial research, led by Lynch and UCSF pulmonologist Homer Boushey, MD, a professor of medicine and an asthma expert at UCSF, as part of the larger Urban Environment and Childhood Asthma (URECA) study, led by James Gern, MD, a professor of pediatrics and medicine at the University of Wisconsin School of Medicine and Public Health in Madison. Researchers aim to discover reasons why asthma is more common and severe among children in poor inner cities.

“Early-life allergies and wheezing illnesses are the two main risk factors for childhood asthma,” Gern said.

To come up with their latest findings, the scientists compared exposure to allergens from cat, cockroach, dog, dust mite and mouse on one hand, and wheezing episodes as reported by parents and allergy as assessed by skin-prick tests on the other.

Through the first three years of life, cumulative exposure to allergy-provoking substances from cats, mice, cockroaches and dust mites – but not from dogs – was associated with more wheezing and allergic reaction in the new study. This was an expected result, based on earlier research.

But this association was reversed when the researchers analyzed exposures for just the first year of life, when greater exposure to certain allergens, those from cockroaches and mice, was associated with less risk of wheezing and allergy at three years.

These results indicate that immune responses might be shaped by exposures during the first year of life differently than they are by later exposures. “These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life may be beneficial,” the researchers wrote in the journal paper.

If the study results are borne out in follow-up research in other populations, it might warrant testing of new strategies, Lynch said, including, “microbial supplementation to inoculate children in early life with appropriate microbes to help protect them against wheezing and allergy.”

Lynch’s own work and research by several others in the field has led her to become convinced that “the composition and function of the gut microbiome strongly influence immune reactions and present a novel avenue for development of therapeutics for both allergic asthma and a range of other diseases.”

According to Boushey, “Strict avoidance of allergens to lower asthma risk has been unsuccessful. Maybe permitting allergen exposures, with increased exposure to the sources of certain microbes, might be more successful in reducing asthma risk.”

Boushey noted that the research team’s new research associating increased bacterial diversity and abundance with lower risk appears to support the “hygiene hypothesis,” which suggests that the increase in the prevalence of allergies and asthma in modern, westernized countries might be an unintended consequence of children being exposed to fewer bacteria in cleaner indoor environments.

“If confirmed by other studies, these findings might even have us think of returning to the patterns of exposure of the 1940’s, when families were larger, food was less processed and sterilized, and children spent a lot of their time outdoors,” he said.

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Oakland Post: Week of December 31, 2025 – January 6, 2026

The printed Weekly Edition of the Oakland Post: Week of – December 31, 2025 – January 6, 2026

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4 days ago

January 2, 2026

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Big God Ministry Gives Away Toys in Marin City

Pastor Hall also gave a message of encouragement to the crowd, thanking Jesus for the “best year of their lives.” He asked each of the children what they wanted to be when they grow up.

Published

1 week ago

December 29, 2025

Oakland Post

From top left: Pastor David Hall asking the children what they want to be when they grow up. Worship team Jake Monaghan, Ruby Friedman, and Keri Carpenter. Children lining up to receive their presents. Photos by Godfrey Lee.

By Godfrey Lee

Big God Ministries, pastored by David Hall, gave toys to the children in Marin City on Monday, Dec. 15, on the lawn near the corner of Drake Avenue and Donahue Street.

Pastor Hall also gave a message of encouragement to the crowd, thanking Jesus for the “best year of their lives.” He asked each of the children what they wanted to be when they grew up.

Around 75 parents and children were there to receive the presents, which consisted mainly of Gideon Bibles, Cat in the Hat pillows, Barbie dolls, Tonka trucks, and Lego building sets.

A half dozen volunteers from the Big God Ministry, including Donnie Roary, helped to set up the tables for the toy giveaway. The worship music was sung by Ruby Friedman, Keri Carpenter, and Jake Monaghan, who also played the accordion.

Big God Ministries meets on Sundays at 10 a.m. at the Mill Valley Community Center, 180 Camino Alto, Mill Valley, CA Their phone number is (415) 797-2567.

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First 5 Alameda County Distributes Over $8 Million in First Wave of Critical Relief Funds for Historically Underpaid Caregivers

“Family, Friend, and Neighbor caregivers are lifelines for so many children and families in Alameda County,” said Kristin Spanos, CEO, First 5 Alameda County. “Yet, they often go unrecognized and undercompensated for their labor and ability to give individualized, culturally connected care. At First 5, we support the conditions that allow families to thrive, and getting this money into the hands of these caregivers and families at a time of heightened financial stress for parents is part of that commitment.”

Published

1 week ago

December 29, 2025

Oakland Post

Costco. Courtesy image.

Family, Friend, and Neighbor Caregivers Can Now Opt Into $4,000 Grants to Help Bolster Economic Stability and Strengthen Early Learning Experiences

By Post Staff

Today, First 5 Alameda County announced the distribution of $4,000 relief grants to more than 2,000 Family, Friend, and Neighbor (FFN) caregivers, totaling over $8 million in the first round of funding. Over the full course of the funding initiative, First 5 Alameda County anticipates supporting over 3,000 FFN caregivers, who collectively care for an estimated 5,200 children across Alameda County. These grants are only a portion of the estimated $190 million being invested into expanding our early childcare system through direct caregiver relief to upcoming facilities, shelter, and long-term sustainability investments for providers fromMeasure C in its first year. This investment builds on the early rollout of Measure C and reflects a comprehensive, system-wide strategy to strengthen Alameda County’s early childhood ecosystem so families can rely on sustainable, accessible care,

These important caregivers provide child care in Alameda County to their relatives, friends, and neighbors. While public benefits continue to decrease for families, and inflation and the cost of living continue to rise, these grants provide direct economic support for FFN caregivers, whose wages have historically been very low or nonexistent, and very few of whom receive benefits. As families continue to face growing financial pressures, especially during the winter and holiday season, these grants will help these caregivers with living expenses such as rent, utilities, supplies, and food.

The funding for these relief grants comes from Measure C, a local voter-approved sales tax in Alameda County that invests in young children, their families, communities, providers, and caregivers. Within the first year of First 5’s 5-Year Plan for Measure C, in addition to the relief grants to informal FFN caregivers, other significant investments will benefit licensed child care providers. These investments include over $40 million in Early Care and Education (ECE) Emergency Grants, which have already flowed to nearly 800 center-based and family child care providers. As part of First 5’s 5-Year Plan, preparations are also underway to distribute facilities grants early next year for child care providers who need to make urgent repairs or improvements, and to launch the Emergency Revolving Fund in Spring 2026 to support licensed child care providers in Alameda County who are at risk of closure.

The FFN Relief Grants recognize and support the essential work that an estimated 3,000 FFN caregivers provide to 5,200 children in Alameda County. There is still an opportunity to receive funds for FFN caregivers who have not yet received them.

In partnership with First 5 Alameda County, Child Care Payment Agencies play a critical role in identifying eligible caregivers and leading coordinated outreach efforts to ensure FFN caregivers are informed of and able to access these relief funds.FFN caregivers are eligible for the grant if they receive a child care payment from an Alameda County Child Care Payment Agency, 4Cs of Alameda County, BANANAS, Hively, and Davis Street, and are currently caring for a child 12 years old or younger in Alameda County. Additionally, FFN caregivers who provided care for a child 12 years or younger at any time since April 1, 2025, but are no longer doing so, are also eligible for the funds. Eligible caregivers are being contacted by their Child Care Payment Agency on a rolling basis, beginning with those who provided care between April and July 2025.

“This money is coming to me at a critical time of heightened economic strain,” said Jill Morton, a caregiver in Oakland, California. “Since I am a non-licensed childcare provider, I didn’t think I was eligible for this financial support. I was relieved that this money can help pay my rent, purchase learning materials for the children as well as enhance childcare, buy groceries and take care of grandchildren.”

Eligible FFN caregivers who provided care at any time between April 1, 2025 and July 31, 2025, who haven’t yet opted into the process, are encouraged to check their mail and email for an eligibility letter. Those who have cared for a child after this period should expect to receive communications from their child care payment agency in the coming months. FFN caregivers with questions may also contact the agency they work with to receive child care payments, or the First 5 Alameda help desk, Monday through Friday, from 9 a.m. to 5:00 p.m. PST, at 510-227-6964. The help desk will be closed 12/25/25 – 1/1/26. Additional grant payments will be made on a rolling basis as opt-ins are received by the four child care payment agencies in Alameda County.

Beginning in the second year of Measure C implementation, FFN caregivers who care for a child from birth to age five and receive an Alameda County subsidized voucher will get an additional $500 per month. This amounts to an annual increase of about $6,000 per child receiving a subsidy. Together with more Measure C funding expected to flow back into the community as part of First 5’s 5-Year Plan, investments will continue to become available in the coming year for addressing the needs of childcare providers in Alameda County.

About First 5 Alameda County

First 5 Alameda County builds the local childhood systems and supports needed to ensure our county’s youngest children are safe, healthy, and ready to succeed in school and life.

Our Mission

In partnership with the community, we support a county-wide continuous prevention and early intervention system that promotes optimal health and development, narrows disparities, and improves the lives of children from birth to age five and their families.

Our Vision

Every child in Alameda County will have optimal health, development, and well-being to reach their greatest potential.

Learn more at www.first5alameda.org.